Negative. Should hook up and fit just fine with only a little adapting. Remember, with the BB in the stock position the measurement from the back of the block to the carb is the same. the difference in length is at the front of the motor.Will there be any issues with the throttle linkage?
If you end up moving the motor to the pass side some with adjustable motor mounts there should only be a little tweaking needed to the linkage.