I tend to agree with CNut, Rick and Mark, but I do see how it could make a difference if the coolant level was low enough not to keep both the top and bottom tanks flooded.
That being said, I have one of the U.S. Radiator Triple Flow radiators. The top nozzle is on the driver side, and the bottom nozzle is on the passenger side, because tanks are baffled to force the coolant down 33% of the cores on the driver side, up the center 33%, and down the passenger side 33%. They advertised 17% better efficiency. If that is true, then how the coolant moves through the radiator has some effect on its efficiency.