My wife and I had cologuard tests a couple of years ago. My came back negative, hers positive. That scared the crap out of us as she had survived breast cancer about eight years earlier. When she had a colonoscopy the doctor removed three small non-cancerous polyps. We asked "No cancer, what about the positive test results?" and he assured us that the Cologuard test will give a positive result if you have polyps, cancerous or not. It would have helped if someone had told us that. We spent about three weeks expecting the worse. The stress level was significant for my wife as she was expecting to learn that she had survived breast cancer just to get colon cancer. The good thing about a cologard test is that it will detect cancer cells much earlier than a colonoscopy can. It finds them will they are still in a microscopic condition which no doctor could see with a scope. Having a better understanding of what the cologuard test does, I heartedly recommend them.